The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease
Identifieur interne : 000294 ( Main/Exploration ); précédent : 000293; suivant : 000295The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease
Auteurs : Julia Vaamonde [Espagne] ; José M. Flores [Espagne] ; Roberto Weisser [Espagne] ; Ram N Iba Ez [Espagne] ; José A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
Abstract
“Pulsatile” administration of levodopa has been invocated a relevant factor for motor fluctuations in Parkinson's disease (PD). We studied dopaminergic sensitivity to apomorphine in 10 parkinsonian patients with motor fluctuations. Patients were tested as follows: the minimal effective dose of apomorphine (MED‐1) was administered in the morning to induce an on response. Fifteen minutes after this motor response had disappeared, an apomorphine infusion was initiated and maintained to ensure on periods of three different durations on different days. Infusion lasted for ∼30, 60 and 90 minutes. Subsequently, the infusion was stopped, and after 15 minutes in the off state, a second bolus of apomorphine (MED‐2) was given. The mean infusion doses were 49.2 ± 5.4, 108.4 ± 10.3, and 150 ± 8.2 mg. These elicited on periods of 48.2 ± 4.1, 110 ± 4.5, and 195 ± 3.8 minutes. The MED‐2 elicited on responses with a duration of 30 ± 4.5, 18.4 ± 3.2, and 11.2 ± 4.1 minutes. The duration of the on response induced by the apomorphine infusions correlated inversely (P < 0.01) with the on induced by the MED‐2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22234
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000391
- to stream Istex, to step Curation: 000235
- to stream Istex, to step Checkpoint: 000091
- to stream Main, to step Merge: 000295
- to stream Main, to step Curation: 000294
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease</title>
<author><name sortKey="Vaamonde, Julia" sort="Vaamonde, Julia" uniqKey="Vaamonde J" first="Julia" last="Vaamonde">Julia Vaamonde</name>
</author>
<author><name sortKey="Flores, Jose M" sort="Flores, Jose M" uniqKey="Flores J" first="José M." last="Flores">José M. Flores</name>
</author>
<author><name sortKey="Weisser, Roberto" sort="Weisser, Roberto" uniqKey="Weisser R" first="Roberto" last="Weisser">Roberto Weisser</name>
</author>
<author><name sortKey="Iba Ez, Ram N" sort="Iba Ez, Ram N" uniqKey="Iba Ez R" first="Ram N" last="Iba Ez">Ram N Iba Ez</name>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A4ED67AF59D3792728005F42FD8DF47C17AB1907</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1002/mds.22234</idno>
<idno type="url">https://api.istex.fr/document/A4ED67AF59D3792728005F42FD8DF47C17AB1907/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000391</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000391</idno>
<idno type="wicri:Area/Istex/Curation">000235</idno>
<idno type="wicri:Area/Istex/Checkpoint">000091</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000091</idno>
<idno type="wicri:doubleKey">0885-3185:2009:Vaamonde J:the:duration:of</idno>
<idno type="wicri:Area/Main/Merge">000295</idno>
<idno type="wicri:Area/Main/Curation">000294</idno>
<idno type="wicri:Area/Main/Exploration">000294</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease</title>
<author><name sortKey="Vaamonde, Julia" sort="Vaamonde, Julia" uniqKey="Vaamonde J" first="Julia" last="Vaamonde">Julia Vaamonde</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Hospital General, Ciudad Real, Spain; 2Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Avenida de Tomelloso s/n 926227800, Ciudad Real 13005</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Castille-La Manche</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Flores, Jose M" sort="Flores, Jose M" uniqKey="Flores J" first="José M." last="Flores">José M. Flores</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Hospital General, Ciudad Real, Spain; 2Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weisser, Roberto" sort="Weisser, Roberto" uniqKey="Weisser R" first="Roberto" last="Weisser">Roberto Weisser</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Hospital General, Ciudad Real, Spain; 2Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Iba Ez, Ram N" sort="Iba Ez, Ram N" uniqKey="Iba Ez R" first="Ram N" last="Iba Ez">Ram N Iba Ez</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Hospital General, Ciudad Real, Spain; 2Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name>
<affiliation wicri:level="1"><country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Neurology, Hospital General, Ciudad Real, Spain; 2Department of Neurology, Clinica Universitaria and Medical School, CIMA, University of Navarra, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="sub">Official Journal of the Movement Disorder Society</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2009-04-15">2009-04-15</date>
<biblScope unit="volume">24</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="762">762</biblScope>
<biblScope unit="page" to="766">766</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">A4ED67AF59D3792728005F42FD8DF47C17AB1907</idno>
<idno type="DOI">10.1002/mds.22234</idno>
<idno type="ArticleID">MDS22234</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>apomorphine boluses</term>
<term>apomorphine infusion</term>
<term>motor complications</term>
<term>pharmacological tolerance</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">“Pulsatile” administration of levodopa has been invocated a relevant factor for motor fluctuations in Parkinson's disease (PD). We studied dopaminergic sensitivity to apomorphine in 10 parkinsonian patients with motor fluctuations. Patients were tested as follows: the minimal effective dose of apomorphine (MED‐1) was administered in the morning to induce an on response. Fifteen minutes after this motor response had disappeared, an apomorphine infusion was initiated and maintained to ensure on periods of three different durations on different days. Infusion lasted for ∼30, 60 and 90 minutes. Subsequently, the infusion was stopped, and after 15 minutes in the off state, a second bolus of apomorphine (MED‐2) was given. The mean infusion doses were 49.2 ± 5.4, 108.4 ± 10.3, and 150 ± 8.2 mg. These elicited on periods of 48.2 ± 4.1, 110 ± 4.5, and 195 ± 3.8 minutes. The MED‐2 elicited on responses with a duration of 30 ± 4.5, 18.4 ± 3.2, and 11.2 ± 4.1 minutes. The duration of the on response induced by the apomorphine infusions correlated inversely (P < 0.01) with the on induced by the MED‐2 of apomorphine. Our findings indicate that a continuous dopaminergic stimulus may induce pharmacodynamic changes associated with tolerance in PD patients. © 2009 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Castille-La Manche</li>
</region>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Vaamonde, Julia" sort="Vaamonde, Julia" uniqKey="Vaamonde J" first="Julia" last="Vaamonde">Julia Vaamonde</name>
</noRegion>
<name sortKey="Flores, Jose M" sort="Flores, Jose M" uniqKey="Flores J" first="José M." last="Flores">José M. Flores</name>
<name sortKey="Iba Ez, Ram N" sort="Iba Ez, Ram N" uniqKey="Iba Ez R" first="Ram N" last="Iba Ez">Ram N Iba Ez</name>
<name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="José A." last="Obeso">José A. Obeso</name>
<name sortKey="Vaamonde, Julia" sort="Vaamonde, Julia" uniqKey="Vaamonde J" first="Julia" last="Vaamonde">Julia Vaamonde</name>
<name sortKey="Weisser, Roberto" sort="Weisser, Roberto" uniqKey="Weisser R" first="Roberto" last="Weisser">Roberto Weisser</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000294 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000294 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Psychologie |area= DanceTherParkinsonV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:A4ED67AF59D3792728005F42FD8DF47C17AB1907 |texte= The duration of the motor response to apomorphine boluses is conditioned by the length of a prior infusion in Parkinson's disease }}
This area was generated with Dilib version V0.6.35. |